烟草科技
2016-03-29 星期二
烟草化学:2020 ,11:30-35
赵俊伟, 赵阁, 李翔, 华辰凤, 尚平平, 王昇, 胡国昌, 郑赛晶, 谢复炜. 卷烟和一次性电子烟抽吸者的吸烟行为[J]. 烟草科技, 2020 (11): 30-35.
ZHAO Junwei, ZHAO Ge, LI Xiang, HUA Chenfeng, SHANG Pingping, WANG Sheng, HU Guochang, ZHENG Saijing, XIE Fuwei. A smoking behavior study on cigarette smokers and disposable e-cigarette users[J]. Tobacco Science & Technology, 2020 (11): 30-35.

卷烟和一次性电子烟抽吸者的吸烟行为
赵俊伟1, 赵阁1, 李翔1, 华辰凤1, 尚平平1, 王昇1, 胡国昌2, 郑赛晶3, 谢复炜1
1. 中国烟草总公司郑州烟草研究院, 郑州高新技术产业开发区枫杨街2号 450001;
2. 湖南中烟工业有限责任公司技术中心, 长沙市雨花区劳动中路386号 410008;
3. 上海新型烟草制品研究院, 上海市虹口区大连路789号 200082
摘要:
为探究卷烟和一次性电子烟抽吸者的吸烟行为,采用自身配对的研究方法,招募66名抽吸卷烟的志愿者,随机分为电子烟Ⅰ和Ⅱ组,两组志愿者分别从抽吸卷烟转换至抽吸烟碱浓度为12、20 mg/mL的电子烟。问卷调查获取志愿者基线资料,CReSS吸烟行为记录仪测试吸烟行为参数,液相色谱-质谱联用法测试尿液中烟碱总代谢物和可替宁,采用尿肌酐校正测试结果。结果表明:①两组志愿者抽吸卷烟的平均每口抽吸容量分别为(50.3±17.2)和(47.9±20.6)mL,持续时间为(1.8±0.7)和(1.7±0.7)s,抽吸间隔为(14.1±9.5)和(14.9±11.7)s;两组志愿者抽吸电子烟的平均每口抽吸容量分别为(57.6±23.1)和(51.1±23.1)mL,持续时间为(1.9±0.7)和(1.7±0.7)s,抽吸间隔为(9.4±9.3)和(11.0±9.3)s。②抽吸卷烟的两组志愿者尿液中烟碱总代谢物的量分别为(6 641.6±3 599.3)和(6 290.3±3 155.5)ng/mg肌酐,可替宁的量分别为(1 047.0±625.4)和(758.9±603.5)ng/mg肌酐;抽吸电子烟的两组志愿者尿液中烟碱总代谢物的量分别为(5 723.1±3 197.8)和(4 381.6±3 271.3)ng/mg肌酐,可替宁的量分别为(918.0±688.5)和(701.4±670.6)ng/mg肌酐(P<0.05)。在小规模人群研究中,由卷烟转换至一次性电子烟,抽吸者的抽吸容量增大,抽吸间隔时间变短,抽吸持续时间延长或无变化,但烟碱暴露水平降低。
关键词:    卷烟    一次性电子烟    吸烟行为    尿液    烟碱总代谢物    可替宁    肌酐   
A smoking behavior study on cigarette smokers and disposable e-cigarette users
ZHAO Junwei1, ZHAO Ge1, LI Xiang1, HUA Chenfeng1, SHANG Pingping1, WANG Sheng1, HU Guochang2, ZHENG Saijing3, XIE Fuwei1
1. Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, China;
2. Technology Center, China Tobacco Hunan Industrial Co., Ltd., Changsha 410008, China;
3. Shanghai New Tobacco Product Research Institute, Shanghai 200082, China
Abstract:
To investigate the smoking behavior of cigarette smokers and disposable e-cigarette users, a self-matching method was adopted. A total of 66 volunteers who smoked cigarettes were recruited and randomly divided into two groups(GroupⅠ and GroupⅡ). The two groups of volunteers were switched to smoke two types of e-cigarettes with different nicotine concentrations (12 and 20 mg/mL), and their general smoking characteristics were collected via questionnaires. CReSS Pocket was used to record the smoking parameters for smokers and e-cigarette users. The contents of total nicotine metabolites and cotinine in volunteers' urine were analyzed by HPLC-MS/MS, and the test results were corrected by urine creatinine. The results showed that:1)The mean puffing volume of the two groups for cigarettes were(50.3±17.2)and(47.9±20.6)mL, puffing duration times were (1.8±0.7) and (1.7±0.7) s, puffing intervals were (14.1±9.5) and (14.9±11.7) s, respectively. The mean puffing volumes of the two groups for e-cigarettes were(57.6±23.1)and(51.1±23.1) mL, puffing duration times were(1.9±0.7)and(1.7±0.7)s, puffing intervals were(9.4±9.3)and(11.0±9.3)s, respectively. 2)The contents of total nicotine metabolites in the urine of the two smoker groups were(6 641.6±3 599.3) and(6 290.3±3 155.5) ng/mg creatinine, the cotinine contents were(1 047.0±625.4) and(758.9±603.5)ng/mg creatinine. The contents of total nicotine metabolites in the urine of two vaping groups were (5 723.1±3 197.8)and(4 381.6±3 271.3) ng/mg creatinine, and the cotinine contents were(918.0±688.5)and (701.4±670.6) ng/mg creatinine(P<0.05). When switched to e-cigarettes, the puffing volume was increased, puffing interval shortened, and puffing duration prolonged or unchanged. However, the contents of total nicotine metabolites in the smokers' urine decreased after switching to e-cigarettes based on this small-scale volunteer study.
烟草化学:2020 ,11:30-35
赵俊伟, 赵阁, 李翔, 华辰凤, 尚平平, 王昇, 胡国昌, 郑赛晶, 谢复炜. 卷烟和一次性电子烟抽吸者的吸烟行为[J]. 烟草科技, 2020 (11): 30-35.
ZHAO Junwei, ZHAO Ge, LI Xiang, HUA Chenfeng, SHANG Pingping, WANG Sheng, HU Guochang, ZHENG Saijing, XIE Fuwei. A smoking behavior study on cigarette smokers and disposable e-cigarette users[J]. Tobacco Science & Technology, 2020 (11): 30-35.

卷烟和一次性电子烟抽吸者的吸烟行为
赵俊伟1, 赵阁1, 李翔1, 华辰凤1, 尚平平1, 王昇1, 胡国昌2, 郑赛晶3, 谢复炜1
1. 中国烟草总公司郑州烟草研究院, 郑州高新技术产业开发区枫杨街2号 450001;
2. 湖南中烟工业有限责任公司技术中心, 长沙市雨花区劳动中路386号 410008;
3. 上海新型烟草制品研究院, 上海市虹口区大连路789号 200082
摘要:
为探究卷烟和一次性电子烟抽吸者的吸烟行为,采用自身配对的研究方法,招募66名抽吸卷烟的志愿者,随机分为电子烟Ⅰ和Ⅱ组,两组志愿者分别从抽吸卷烟转换至抽吸烟碱浓度为12、20 mg/mL的电子烟。问卷调查获取志愿者基线资料,CReSS吸烟行为记录仪测试吸烟行为参数,液相色谱-质谱联用法测试尿液中烟碱总代谢物和可替宁,采用尿肌酐校正测试结果。结果表明:①两组志愿者抽吸卷烟的平均每口抽吸容量分别为(50.3±17.2)和(47.9±20.6)mL,持续时间为(1.8±0.7)和(1.7±0.7)s,抽吸间隔为(14.1±9.5)和(14.9±11.7)s;两组志愿者抽吸电子烟的平均每口抽吸容量分别为(57.6±23.1)和(51.1±23.1)mL,持续时间为(1.9±0.7)和(1.7±0.7)s,抽吸间隔为(9.4±9.3)和(11.0±9.3)s。②抽吸卷烟的两组志愿者尿液中烟碱总代谢物的量分别为(6 641.6±3 599.3)和(6 290.3±3 155.5)ng/mg肌酐,可替宁的量分别为(1 047.0±625.4)和(758.9±603.5)ng/mg肌酐;抽吸电子烟的两组志愿