Abstract: To gain knowledge on the utilization of flue-cured tobacco hybrids in Zimbabwe and to take it as a reference for improving the ability of flue-cured tobacco breeding in China, the concept and strategy of flue-cured tobacco breeding, leaf research work and general program of hybrid utilization, the regional test, popularization and application of hybrids in Zimbabwe were introduced and analyzed on the basis of on-site investigation and research. In Zimbabwe, the flue-cured tobacco varieties bred in recent 20 years were all male sterile hybrids. Hybrid varieties had the advantage in speeding up breeding of new multi disease-resistant varieties. However, multi-resistant parents were the basis for the aggregation of resistances to more diseases in hybrids. Therefore, the breeding of superior parents with multi-resistant traits was the key of hybrid utilization, and effective resistant resources to most of major diseases in Zimbabwe tobacco production were screened out from germplasm resources. The resistance genes were successfully transferred into flue-cured tobacco cultivars, and a number of quality flue-cured tobacco parent materials with resistances to several diseases were bred, which built a foundation for the breeding of multi-resistant hybrids. Comparing with Zimbabwe practice, the number of quality multi-resistant hybrids independently bred and popularized in flue-cured tobacco production was less in China; the fundamental cause was the serious lack of quality parent materials with resistances to several diseases. Therefore, the research and utilization of disease-resistant germplasm in flue-cured tobacco breeding should be strengthened in China. At the same time, the breeding of quality multi-resistant parent materials should also be valued for making full use of hybrids.