Abstract: The contents of 7 heavy metals, Cr, Ni, As, Cd, Se, Hg and Pb, in 1 100 tobacco leaf samples from 11 major producing provinces in China were determined by ICP-MS(Inductively coupled plasma-mass spectrometry). The content data were analyzed from the points of regionalism and correlation. The results showed that: 1) The samples from Hubei exhibited the lowest comprehensive level(L) of the 7 heavy metals and the samples from Hunan the highest. 2) The accumulation of Cr in tobacco significantly positively correlated with that of Ni, as did As with Pb, there might exist synergic absorption between Cr and Ni and between As and Pb in tobacco. 3) The contents of the 7 heavy metals in samples from some provinces presented highly significantly positive correlation, which was probably caused by local soil conditions and special industrial-agricultural pollution, it suggested a very high possibility of homologous pollution.