Abstract: In order to provide more references for the design and development of filters for slim cigarettescircumference (17.0 ±0.1) mm, five cellulose acetate tow specifications, 3 filter pressure drops and 4 filter ventilation rates were used to design a total of 15 filter samples and 60 slim cigarette samples based on single factorial experimental design principle. The nicotine filtration efficiencies affected by the above parameters were investigated. The results showed that:For slim cigarettes of different cellulose acetate tow specifications, 1) nicotine filtration efficiency significantly positively correlated to the filter ventilation rate when filter pressure drop was fixed. The influence extent of the filter ventilation rate on nicotine filtration efficiency ascended first and then descended with the increase of filter pressure drop. Nicotine filtration efficiency increased by 0.64%-1.00% when the filter ventilation rate raised by 10%; 2) nicotine filtration efficiency significantly positively correlated to the filter pressure drop when the filter ventilation rate was fixed, it increased by 1.20%-1.40% when the filter pressure drop raised by 100 Pa; 3) the filtration efficiency to nicotine decreased with the increase of denier per filament (dpf) and the decrease of total denier.