Abstract: In order to study the transfer behavior of non-phthalate plasticizers during smoking, a GC/MS-SIM (gas chromatography/mass spectroscopy-selective ion monitoring) method was used to analyze the distribution of 12 non-phthalate ester plasticizers (including DEA, DIBA, DBA, BXA, DEHA, TEC, TBC, ATBC, TBP, TPP, TOP and DEDB) in total particulate matter (TPM) of mainstream cigarette smoke, filter, cut tobacco in smoked butt and tobacco ash. The results showed that:1) The transfer rates of the 12 non-phthalate plasticizers to TPM and their retention rates in filter and in smoked butt were 8.37%-32.38%, 3.18%-41.66% and 1.13%-14.43%, respectively. 2) The sums of transfer rate to TPM and retention rates in filter and smoked butt for four kind non-phthalate plasticizers (aromatic carboxylic acid ester, aliphatic dibasic acid ester, citric acid ester and phosphate ester) were 27.46%-50.29%, 22.85%-75.82%, 26.25%-41.11%, 14.97%-55.41%, respectively. 3) The 12 non-phthalate plasticizers were not detected in cigarette ash. 4) The transfer rates of the 12 non-phthalate plasticizers to TPM decreased with the increase of their adding amount. 5) For non-phthalate plasticizers of the same kind, the transfer rate to TPM decreased with the increase of relative molecular weight, and the transfer rates of isomers were higher than those of normal compounds.