Abstract: Drought is one of the main factors that restrict the normal growth and development of plant, it is also a key research field in abiotic stress. In order to reveal the molecular improvement effect and mechanism of tobacco drought resistance, genes related to tobacco drought resistance were introduced. The research progress on drought resistance related genes in tobacco was reviewed from three aspects:transcription factor, signal transmission, drought resistance functional genes. It was found that there were many problems in current research on drought resistance related genes in tobacco, such as single technological method, less research on tobacco genes, lack of in-depth longitudinal experiments and so on. The future research prospects, including various molecular biological techniques, the response mechanism of tobacco against drought stress, and the construction of tobacco drought resistance gene resource library, were proposed.