Abstract: In order to study the factors that influence the releases of interested components, such as nicotine, carbonyl compounds and other components from e-cigarette aerosols, the effects of device power, puffing number and glycerol ratio on the releases of nicotine, carbonyl compounds, TSNAs and heavy metals were investigated. The results showed that:1) The releases of the interested components differed significantly among different types of e-cigarettes. Device power was an important factor affecting the releases of various components from e-cigarette aerosols, the releases of nicotine, carbonyl compounds, TSNAs and heavy metals increased with the rise of device power. 2) Device power influenced the releases of carbonyl compounds most significantly, the releases of carbonyl compounds on per unit aerosol collected mass (ACM) basis increased with the rise of device power, while those of nicotine and TSNAs were basically unchanged. The release of Ni on per unit ACM basis was largely unchanged when the device power was above 80 W. 3) The releases of nicotine, carbonyl compounds and TSNAs from e-cigarette aerosols were affected by puffing number, however the releases of the heavy metals from high power device were basically unchanged when puffing number was higher than 20. 4) Glycerol/PG ratio affected the releases of carbonyl compounds. The increase of glycerol/PG ratio accelerated the releases of carbonyl compounds rapidly, especially formaldehyde release.