Abstract: To develop functional materials with high retention ability for hydrogen cyanide(HCN)and crotonaldehyde in cigarette smoke, 20 tetrabutyl ammonium hydroxide-amino acid ionic liquids (TBAILs) were prepared. The structures of TBAILs were characterized, and their toxicant-reducing performance in smoke was evaluated. The effects and stability of TBAILs on reducing the releases of HCN and crotonaldehyde in mainstream cigarette smoke were evaluated in the form of paper-cellulose acetate dual composite filter. The results showed that:1) The structures of TBAILs were confirmed by Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectroscopy. In addition, thermogravimetric analysis indicated that TBAILs had good thermal stability under 150℃. 2) The adsorption performance tested on a bespoke device revealed that all of the 20 TBAILs had substantial reductions for HCN (>80%), wherein 13 TBAILs also showed a high efficiency for crotonaldehyde (>60%). 3) When tetrabutyl ammonium-threonine ionic liquid (N₄₄₄₄ Thr) was applied to cigarette filters at 10 mg/cig., compared with the control cigarettes, the releases of HCN and crotonaldehyde in mainstream smoke were reduced by 50.8% and 27.7%, respectively, and the smoke sensory quality did not change obviously. The toxicant-reducing performance ofN₄₄₄₄ Thr was maintained after storing for 3 months.