Abstract: In order to clarify the influences of different soil amendments on the growth and development of tobacco and the contents of pollutants in tobacco, the effects of applying sepiolite and biochar on botanical traits of flue-cured tobacco, biomasses of different parts of tobacco at different growing stages, root development and pollutant absorption under the combined pollution of metalaxyl and cadmium were studied via pot experiments. The results showed that adding sepiolite or biochar at the rate of 20 g·kg^-1 promoted the growth of tobacco and biomass accumulation to different extents. Compared with the control, the equal application of sepiolite and biochar(at the rate of 10 g·kg^-1 each)significantly(P < 0.05) increased the height, leaf number, root biomass, root top ratio, main root length and root volume of tobacco plant. Applying sepiolite, biochar or their combination decreased the metalaxyl content in leaves and roots, and shortened the half-life of metalaxyl in leaves, however there were no significant differences among the different treatments. In addition, the three soil amendments delayed the cadmium absorption peak of tobacco roots and leaves until the flower-bud appearing stage and decreased the cadmium enrichment coefficients in tobacco roots and leaves. Therefore, the equal application of sepiolite and biochar is an effective means for improving the soil equality in tobacco fields since it can significantly promote tobacco growth and development by reducing the harms of cadmium and metalaxyl to tobacco plants.