Abstract: To develop functional materials that can reduce phenol release in cigarette smoke, 36 natural deep eutectic solvents (NADESs) were designed and prepared based on the characteristics that phenolic hydroxyl groups could easily form hydrogen bonds. The structures and thermal stability of the synthesized products were characterized by Fourier transform infrared spectroscopy (FT-IR), elemental analysis (EA) and thermogravimetric analysis(TG). The performances of the synthesized products in reducing phenol release in cigarette smoke were evaluated by a simulating device for screening the harm-reducing abilities of these filter additives in mainstream cigarette smoke. The results showed that: 1)The FT-IR and EA results suggested that the NADESs were successfully synthesized. TG analysis indicated that the NADESs had good thermal stability up to 150 ℃. 2)Thirteen NADESs reduced phenol release in mainstream cigarette smoke by more than 30%. Among them, choline chloride-levulinic acid (ChCl-LA), betaine-levulinic acid (Bet-LA), choline chloride-DL-lactic acid (ChCl-Lac), L-proline-DL-lactic acid (Pro-Lac) and choline chloride-fructose (ChCl-Fru)reduced phenol release by more than 40%. In summary, NADESs could effectively reduce phenol release in cigarette smoke and they could be prepared with a simple, green and low cost process.