Abstract: To improve the test efficiency of moisture content in tobacco materials and to optimize the working condition regulation response of heat-moisture treatment units, on the basis of a Newton drying kinetics model, the linear correlation between the drying rate and moisture content of tobacco materials within the moisture content range of 10%-30% was obtained by using a macro-calorimetry analyzer. A rapid detection method for the moisture content in tobacco was developed as a result, and its accuracy and repeatability were assessed. The results showed that: 1) The relative error and coefficient of variation of detection of 5 standard samples were less than 2.89% and 3.71% respectively, which indicated that the method featured a high accuracy and good repeatability. 2) The experimental parameters of the method were drying rate constant k -0.004, drying temperature at 100 ℃, sample mass around 0.5 g, and the detection time around 20 min. 3) The method had a good universality. The absolute deviations of the test data for samples of 4 leaf grades, 3 stalk positions and 5 moisture contents from Nanping, Fujian Province in 2019 were less than 0.46%. 4) The correlation coefficient (R) between this method and the conventional oven method reached 0.995 6. 5) Comparing with 4 commonly used moisture content determination methods, the developed method has a high precision, short detection time and accurate control.