Abstract: In order to investigate the differences in mass fractions and compositions of volatile components in domestic cigars, headspace-solid phase microextraction and gas chromatography-mass spectrometry (HS-SPME-GC-MS) were used to determine the volatile components in 12 cigar samples of different specifications produced by four Chinese manufacturers, and the obtained data were analyzed by one-way ANOVA (analysis of variance) and cluster analysis. The results showed that: 1) A total of 42 volatile components were detected in the 12 samples, including 9 alcohols, 4 aldehydes, 2 esters, 5 acids, 11 ketones, 9 heterocyclic compounds, and 2 other compounds. 2) All of the 12 cigar samples contained phytol, ethyl palmitate, benzoic acid, farnesyl acetone, megastigmatrienone, neophytadiene, nicotine, myosmine, 2, 3'-bipyridine, etc., which might represent the main volatile components of domestic cigars. 3) The mass fractions of most volatile components differed significantly among the 12 samples (P < 0.05), and some of the volatile components had local characteristics. For example, the mass fraction of farnesyl ketone was generally higher in Shandong cigar samples, those of phytol and alkaloid were generally higher in Sichuan cigar samples, that of geranyl acetone was generally higher in Anhui cigar samples, and α-terpineol and fenchyl alcohol were detected in all Hubei cigar samples. 4) The results of cluster analysis for mass fractions of the 42 volatile components were consistent with those of difference analysis for alkaloid mass fractions. Whether the compositions and mass fractions of alkaloids can be used to distinguish cigar manufacturers still needs to be further verified.