Abstract: In order to evaluate the differences in typical heated tobacco products of different brands, the chemical components in the aerosol particulate matters from 19 heated tobacco product samples were determined by gas chromatography-quadrupole/exactive orbitrap mass spectrometry (GC-Q Exactive Orbitrap MS). Differential statistical analysis of chemical component types and relative mass fractions was performed on the particulate matter. The results showed that: 1) Chemical components in aerosol particulate matters from the heated tobacco product samples of the same brand were similar in type and relative mass fraction. 2) Based on PCA score plots from the selected samples, there was a clear distinction between different brands of heated cigarette samples. Foreign heated cigarette samples had a relatively concentrated spatial distribution and were clustered by brand, while the distribution of domestic heated cigarette samples was relatively discrete. 3) Compared to the selected domestic heated cigarette samples, there were 56 and 9 components in the aerosol particulate matters from the foreign heated cigarette samples that significantly decreased and increased in their mass fractions, respectively.