Abstract: To develop a numerical model to describe the dynamic heat transfer process and release of major aerosol constituents from the tobacco section of electrically heated tobacco products, the porous medium theory and tobacco reaction kinetics were combined to study heat transfer, aerosol generation and transfer, and the release behavior of moisture, glycerol, and nicotine from the tobacco section during heating. The model was solved numerically using Fluent computational fluid dynamics software. Based on the heat transfer similarity criterion for the porous media, an experimental sleeve device with a 4-fold scaled-up of the prototype tobacco stick was designed and built, and the temperature distribution within the sleeve device was measured. The predictive ability of the model was validated with the measured temperature data and tested puff-by-puff residuals of the three major constituents in the prototype tobacco stick. The results showed that the simulated values were in good agreement with the experimental values; the average errors of the simulated values by the model for the puff-by-puff residuals of moisture, glycerol, and nicotine in the tobacco section were 5.02%, 12.41%, and 19.97%, respectively. The model can be used to evaluate the heat transfer within the tobacco section, the temperature of 76.51% volume fraction of the tobacco materials was below 150 ℃ in this simulation study, and the low temperature affected the release rates of glycerol and nicotine. This numerical model can be used to optimize the design of heating and formulation of tobacco constituents for heated tobacco products.