Abstract: To study the effect of stick structure on aerosol temperature from heated tobacco products (HTPs), heated tobacco stick samples of different structures with a fixed total length of 45 mm were designed and manufactured, and a method for determining aerosol temperature and aerosol collected mass (ACM) from the HTP was established. The influence of binary, ternary and quaternary structures of HTP stick on aerosol temperature and ACM release were investigated. The results showed that: 1)The maximum temperatures of aerosol from the HTPs with different binary stick structures were in the range of 106-137 ℃, and those with different ternary structures were 40-85 ℃. The maximum aerosol temperature from the HTPs with different quaternary stick structures reached 72 ℃ at the first and second puffs, and those at the subsequent puffs were lower than 50 ℃. 2)The cooling effect of the cavity section was significantly lower than that of the tobacco section and the solid cellulose acetate section. The lengths of the tobacco section and the solid cellulose acetate section should not be too long, and the quaternary stick structure had the best aerosol cooling effect for HTP. When the length of the cooling section ranged from 12 to 18 mm, the puff-by-puff maximum aerosol temperature could be reduced to below 42 ℃. 3)For HTP sticks with quaternary structure, no significant rule was found in the weight loss of HTP stick at the same puff number with the increase of the inner diameter of the cavity, but the ACM generally increased. As the air permeability of cigarette paper increased, the weight loss of HTP stick at the same puff number gradually increased, but there was no significant pattern for ACM release. With the decrease of the cavity section length and the increase of the solid cellose acetate section length, the stick weight loss and ACM of the HTP at the same puff number generally decreased gradually.