Abstract: In order to investigate the loss and transfer of different additives during the production process of reconstituted tobacco materials for heated tobacco products (HTPs), their migration to filter sections during storage, and their transfer during smoking, a set of GC-MS analysis methods suitable for n-alkanes, fatty alcohols, fatty aldehydes and fatty ketones in the tobacco sections, filters and mainstream smoke of HTPs were established. During production, additives were applied to the reconstituted tobacco materials to prepare the tobacco sections of HTPs. The mass fractions of four types of additives in the tobacco sections, filters and mainstream smoke particulate phases of HTPs were determined, and the retention and distribution of these additives in HTPs and their transfer behavior during smoking were analyzed. The results showed that: 1) The spiked recoveries of 43 compounds in various matrices ranged from 88.4% to 110.9%, the relative standard deviations ranged from 0 to 8.5%, and the intra- and inter-day RSDs were within 10% for most of the compounds. 2) For the homologues, as the carbon chain length in the molecules increased, the retention rates of the compounds in a whole HTP stick gradually increased, while their migration rates to the filter gradually decreased, and their transfer rates to the particulate phase of mainstream smoke and their retention rates in the filter first increased and then decreased. 3) The retention rates of different types of additives in a whole HTP stick were quite different, which mainly related to the boiling points of the additives. The retention rates of fatty alcohols (12.4%-72.4%) were the highest, followed by those of fatty ketones (1.6%-51.3%), with n-alkanes being the lowest. 4) The migration rates of different types of additives to the filter were generally distributed between 10% and 90%, except for n-alkanes (8.8%-36.4%). The aliphatic ketones had the highest filter migration rates. The differences in the filter migration rates of different types of additives were mainly related to the activity of their functional groups and stability molecular structures. 5) Except for n-alkanes, the transfer rates of the other three types of compounds to the particulate phase of the mainstream smoke were about 0-30%, and those of the fatty aldehyde additives with medium to low boiling points were greater. 6) The differences in the filter retention rates between the additives were small, the filter retention rates of alcoholic and ketone additives were slightly higher than those of aldehydes, which might be related to the high volatility of aldehyde additives.