Abstract: To comprehensively assess the quality of flue-cured tobacco, an entropy weight method and a modified Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method were used to evaluate the appearance, sensory quality, and routine chemical composition consistency of 114 flue-cured tobacco samples. The proximity for the appearance, sensory quality, chemical composition, and comprehensive quality were obtained, and the correlations between the different comprehensive quality indices and each quality proximity were analyzed using a simple correlation analysis method. The results showed that: 1) The weights of the appearance, sensory quality and chemical composition calculated by the entropy weight method were about 0.316, 0.380, and 0.304, respectively. 2) The flue-cured tobacco with fresh-sweet flavor from Taiping Town, Huili County, Liangshan Prefecture, Sichuan Province; Miyang Town, Mile City, Honghe Prefecture, Yunnan Province; Lin?an Town, Jianshui County, Honghe Prefecture, Yunnan Province; Lixi Town, Huili County, Liangshan Prefecture, Sichuan Province; and Cida Town, Dechang County, Liangshan Prefecture, Sichuan Province had better comprehensive quality. 3) The indices that positively correlated with the comprehensive quality of tobacco with fresh-sweet flavor included color intensity, body, oil, color and leaf structure, the vast majority of sensory quality indices (dryness, mellowness, aroma quantity, offensive odor, volatility, aftertaste, aroma quality, extent, irritation, smoothness and industrial usability), and total alkaloids and reducing sugar/total sugar ratios in leaf chemical compositions.