Abstract: To investigate the effects of combined cavity filter structures on routine chemical component releases in mainstream cigarette smoke, cigarette samples of three specifications (conventional, demi-slim and slim) were prepared and their draw resistances measured. The releases of total particulate matter (TPM), tar, nicotine and CO in mainstream cigarette smoke at different cavity depths, cigarette draw resistances, and cross-sectional areas of the cavity filters were analyzed and ridge regression models were developed. The results showed that: 1) Using simple correlation analyses, the releases of TPM, tar and nicotine in mainstream smoke of the three cigarettes were significantly affected by the cavity depth and cigarette draw resistance. 2) In the partial correlation analysis, in the case of control variables, the releases of TPM, tar and nicotine in the mainstream smoke of the conventional cigarettes were significantly affected by its draw resistance. The releases of TPM, tar and nicotine in the mainstream smoke of demi-slim cigarettes were significantly affected by its cavity depth and cross-sectional areas of the cavity filters. The effects of cavity depth, cigarette draw resistance and cross-sectional areas of the cavity filters on the routine chemical component releases in the mainstream smoke of the slim cigarettes were not significant. 3) The regression models of TPM, tar and nicotine releases in mainstream smoke of cigarettes of the three specifications were obtained by ridge regression analysis, which could be used to predict the effects of filter structure variations on these routine chemical components in mainstream cigarette smoke. The relative errors between the predicted and measured values were mostly within ±5%.