Abstract: To investigate the influences of different tobacco material formulas on the production process quality of paper-making reconstituted tobacco, the process quality indexes (precipitate content, beating degree, etc.) of tobacco material formulas with different proportions of tobacco stem, scrap and dust in extraction, pulping and base sheet making processes were comparatively analyzed both in the laboratory and in a production line, and the sensory quality of reconstituted tobacco was evaluated. The results showed that: with the increase of the proportion of tobacco dust in the formula, 1) the precipitate content in the primary extraction solution increased, while that in the secondary extraction solution did not change significantly. The dryness of the primary and secondary extrusions decreased as the proportion of tobacco stem decreased. The mixed extraction process reduced the precipitate content in the primary extraction solution and promoted the dryness of the primary and secondary extrusions. As the proportion of tobacco stem decreased, the extraction rates of the primary and secondary water-soluble extracts of tobacco materials decreased; 2) the beating degree of tobacco pulp increased and the wet weight decreased; 3) there was no obvious change in the drainage amount of tobacco pulp and the one-way retention rate. As the proportion of tobacco stem decreased, the tensile strength, tearing degree and permeability of the base sheet decreased. Reducing the stem proportion could improve the sensory quality of the reconstituted tobacco.