Abstract: To enhance the utilization efficiency of logistics resources in the tobacco industry, to take advantage of logistics economies of scale and to reduce the overall logistics operating costs, a total cost model for regional logistics hubs was developed based on the key indicators of transportation and operating costs. The genetic algorithm was used for selecting an optimal site of regional distribution center. The simulation results showed that: 1) The proposed regional logistics facility could integrate the existing logistics resources, elevate scale effects, and achieve high-performance network operations. 2) Compared with the single-point logistics distribution mode, the regional logistics distribution mode reduced the total cost by 7.75%, maximized the cost-effectiveness of the logistics network. 3) The proposed site selection approach for regional logistics distribution centers exhibited an ability of self-adaptive to the geographical and operational characteristics of different provinces, it provided a technical basis for logistics network planning in the tobacco industry.