Abstract: In tobacco processing, key operations such as threshing and redrying, cut tobacco processing, and cigarette making commonly involve complex multiphase flows, including gas-solid two-phase flow and gas-liquid-solid three-phase flow. The flow characteristics directly affect the transportation, separation, mixing, and heat and mass transfer efficiency of tobacco materials. Multiphase flow process simulations based on the computational fluid dynamics-discrete element method (CFD-DEM) can analyze the momentum, heat, and mass transfer between fluids and particles at the particle scale, providing an effective approach for studying multiphase flow mechanisms and optimizing industrial processes in tobacco processing. However, due to the complex morphology, multicomponent and multiscale characteristics of tobacco particles, as well as the intricate multiphase coupling interactions involved in processing, current CFD-DEM methods still face limitations in realistic particle representation, complex behavior characterization, interphase interaction modeling, and industrial-scale applications. To address these challenges, this paper provides a review of multiphase flow process simulation technology for tobacco processing based on the CFD-DEM method, focusing on the development of key technologies such as tobacco particle modeling, deformation and breakage behavior characterization, gas-solid drag models, and large-scale computational acceleration. Furthermore, this paper summarizes the applications of CFD-DEM methods in typical tobacco multiphase flow processes. Future efforts should further improve the computational efficiency and model accuracy of CFD-DEM, strengthen its integration with data-driven technologies, and promote the digital, intelligent, and precise development of tobacco processing.