Abstract: The main chemical components and several mid/micro elements in cutters of flue-cured tobacco grown in 2000 to 2004 and 1983 to 1984 were compared. The results showed that the average contents of nicotine and total nitrogen increased from about 1.0% and 1.25% in 1983-1984 to about 2.5%-3.0% and 2.0% in 2000 to 2004, while the reduced sugar decreased from 24.43% to 22%. The potassium and chlorine ions contents in some grown areas changed dramatically, although no obvious change was observed between different crop years in general. The zinc and manganese contents increased to some extent, calcium content decreased significantly, and the magnesium content changed slightly.