Abstract: In order to reduce protein content in stem effectively and improve the quality of paper making process sheet tobacco,organic acid salt or alkali treatment agent was added along with process condition modification to increase the amounts of protein dissolved from stem or stem slurry while keeping the process flow of sheet tobacco making unchanged.The results showed that:1) the effect in stem slurry processing was better than that in stem processing;2) the best treatment agent was KOH,the preferable conditions were:temperature 25℃,treating time 2 hrs,the solvent ratio of treatment solution 1:4,and the concentration of treatment agent 1.0%.The protein content in stem slurry reduced by 60.4% compared with the control.The offensive odors and after taste of paper making process sheet tobacco was improved to a certain extent by alkali solution treatment.