Abstract: In order to ensure the security of production and operation data,the security of decision-making and management data,and uninterrupted operation of the application system against any artificial or natural casualties,a key technical scheme of disaster tolerance center in the information system of China National Tobacco Corporation was outlined based on the analysis of status quo of the information system,which included the targets of system restoration,selection of data copying program,technical framework of data copying,network configuration of disaster tolerance center,wide area network between master center and backup center,backup network for the backbone nets of the industry,information security of disaster tolerance network,etc.