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前胡、矮地茶、槐米复合提取物在卷烟中的应用及其毒理学评价

Application of Composite Extraction of Radix peucedani,Herba ardisiae Japonicae and Flos sophorae Immaturus in Cigarette and Toxicological Assessment of the same

  • 摘要: 为了降低吸烟的危害,对添加前胡、矮地茶、槐米复合提取物卷烟的燃吸品质及其烟气的危害性分别进行了感官评价和毒理学评价。结果表明:①含2‰该提取物的卷烟,香气丰满,烟味谐调,余味舒适;②含2‰该提取物的卷烟烟气急性毒性、染色体损伤的遗传毒性、细胞膜脂质过氧化损伤均明显低于未加提取物的卷烟;没有阳性致突变反应;哺乳动物细胞的细胞毒性和染色体畸变稍低于未加添加提取物的卷烟,但没有统计学差异。

     

    Abstract: The sensory evaluation and toxicological assessment of cigarette samples spiked with the composite extraction of Radix peucedani,Herba ardisiae Japonicae,and Flos sophorae Immaturus were conducted.The results showed that:1) The cigarette containing 2‰ of the extraction was rich in aroma,balance in taste and comfortable in aftertaste;2) The acute toxicity,genetic toxicity of chromosome lesion and cell membrane lipid peroxidation lesion were obviously weaker than the control.No bacterial mutagenicity was found in Ames test.Although the cytotoxicity and chromosome aberrations in tested mammal were slightly lower than the control,the difference was of no statistic significance.

     

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