Abstract: Sixty C3F samples of flue-cured tobacco leaves were collected from Zhumadian to analyze the relationship between physical-chemical indexes and full flavor style degree of leaves with correlation analysis and stepwise regression analysis. The results showed that: 1) the full flavor style degree of leaves significantly positively correlated with leaf thickness, potassium,megastigmatrienone A,megastigmatrienone B, and megastigmatrienone C;extremely significantly positively correlated with volatile base,kaempferol-3-rutinoside, furfural, furfural alcohol,5-methyl furfural,and megastigmatrienone D;while significantly negatively correlated with reducing sugar;extremely significantly negatively correlated with linalool, farnesylacetone, geranyl acetone, β-ionone,2-acetyl furan; 2) there was an extremely significant regression relationship between full flavor style degree of leaves and furfural,5-methyl furfural,2-acetyl furan,geranyl acetone, which were the major components affecting the full flavor style degree of leaves,and determined about 88.7% of the changes of full flavor style degree of leaves.