Abstract: In order to find a better method for synthesizing monomenthyl succinate,the compound was synthesized by subjecting the starting materials,succinic anhydride and menthol to microwave radiation in the presence of HClO₄-SiO₂ as a catalyst. The structure of the resultant compound was characterized by IR,¹H NMR and ¹³C NMR. The synthesis parameters were optimized by orthogonal test and compared with traditional synthesis method. The results showed that:1) The synthesized compound was the target product. 2) The optimum condition was microwave power 400 W,reaction time 14 minutes,mole ratio of succinic anhydride to menthol to HClO₄-SiO₂ 1.2:1:0.012,under which the average yield of the compound was 90.1%. 3)HClO₄-SiO₂ could be reused for 3 to 4 times. Under microwave radiation and taking HClO₄-SiO₂ as a catalyst was an efficient and simple way for the synthesis of monomenthyl succinate.