Abstract: In order to investigate the influences of meteorological factors in southern Hunan tobacco growing areas on the physical and chemical indicators of flue-cured tobacco, the meteorological data over 30 years were collected and their correlation with the physical and chemical indicators of tobacco leaves were analyzed with descriptive statistics and correlation analysis. The results showed that:1) In southern Hunan tobacco growing areas, the coefficient of variation of temperature and sunshine hour in March were higher than in other months, the monthly active accumulated temperature in March was the lowest, and the years with average daily temperature lower than 13℃ in March accounted for 71.2% of all the 30 years. 2) In the 30 years, the active accumulated temperature from April to July were 2981.40℃, which was beneficial to tobacco growth in field during its growth period; but in 18.0% of the 30 years, the average temperature was above 35℃ in July, at that time"heat-forced maturity"or higher nicotine content tobacco tended to occur, and the quality of tobacco leaves was affected accordingly. 3) The correlation of precipitation, sunshine hour and evaporation in March and June with single leaf weight, stem content and moisture content of grade C3F was relatively significant. 4) The meteorological factors in southern Hunan tobacco growing areas were more significantly correlative with chemical indicators (P<0.05) of C3F leaves than with physical indicators; among the four main meteorological factors, precipitation and sunshine hours were more significantly correlated with chemical indicators (P<0.05).