Abstract: To improve the stability of cross-regional and cross-factorial data transmission between network systems of different platforms,an integration configuration for cross-factorial application was developed by using SAP XI as the hub of information processing,conversion,receiving and transmitting on the basis of the message-oriented middlewares at provincial tobacco industrial company and factories levels to configure transmission channel and integrate the SAP ERP system of the company and the application systems of affiliated cigarette factories.The results of application showed that the system ran stably and reliably,data processing was accurate and effective,the data transmission was perfect and successful,the average time of uplink and downlink data transmission was 1.938 and 0.510 seconds,respectively,which met the requirements of business operation.