Abstract: In order to find out the key climatic factors influencing the formation of flavor type of flue-cured tobacco, the samples of flue-cured tobacco of different typical flavor types were collected from the main tobacco planting areas in China and analyzed with mathematical statistics. The results showed that: 1)the difference in climatic factors between different flavor types was mainly attributed to regional climatic factors; 2) the difference of climatic factors at field stage was mostly of seasonal dependence such as temperature, humidity, vapor pressure, etc; 3) the difference of interaction between climatic factor and flavor type at field stage was mainly caused by light irradiation. Therefore, the difference of climatic factors should be taken into full account in tobacco production and the resources should be rationally assigned to improve the quality and style of tobacco.