Abstract: The correlation analysis and multivariate linear regression analysis of five toxicological indexes (MR value, SCE frequency, micronucleus frequency, cell death rate and death rate of mouse by secondhand smoke exposure)and five main chemical indexes of cigarette smoke (tar, nicotine, CO, TSNAs and BaP)of cigarette smoke of 22 brands were carried out.The results showed that there existed some correlations between the toxicological indexes and harmful chemical components in cigarette smoke, in which TSNA was the most important factor influencing MR value, SCE frequency and cell death rate (P <0.01), while the micronucleus frequency or death rate of mouse by secondhand smoke exposure was not correlated to tar, nicotine, CO, TSNAs and BaP (P >0.05).Therefore, substantial TSNAs reductions in cigarette smoke would probably reduce the hazards of smoking to health.