Abstract: Combining with the experience of Longyan Cigarette Factory, the course of MES implementation were described, including the setting up of MES project team, selection of collaborators, investigation of business requirements and system developing, personnel training, data preparing, simulation running and customization, test running and system switching.The 3 factors (data, technology and personnel) influencing the running effect of MES were analyzed.The running status of MES must be reviewed and improved regularly, in this way, to raise the level of MES application further.