Abstract: The design of intellectual interface chip SPC3 based on single chip microcomputer AT89C52 and realization of hardware were introduced, the efficiency of data collecting and monitoring system was increased by PROFIBUS and RS-485 interface circuit.SPC3 was used in the electric control system of ZJ19E cigarette making and tipping machine combination, its software design including the initialization programing of AT89C52 microcontroller and SPC3, the program was stored directly in the inner flash memory of AT89C52, the peripheral circuit and time sequential control were simple, it fulfills the characters of real time, higher accuracy and reliability required by control system in cigarette making and tipping machine combination.