Abstract: Basic principles of process design were suggested for automatic material handling system in accordance with the character and status quo of the tobacco enterprises.The solutions to problems for designing the automatic material handling system for the enterprises,such as building storage on the second floor,small batch blending, adaptability to package of tobacco leaf,dispatch efficiency of the finished product,collection and stochastic supply of auxiliary material,automatic material handling system for spare parts,controlling and collecting of information, fire fighting and etc.were also proposed.