Abstract: The experiment was conducted under the condition of assuring the sufficient supply of nitrogen using differential subtract method to study the effects of with or without some nutritional elements supplement on the growth of tobacco yield and quality.The results showed that single leaf weight of-K treatment was obviously lower than that of FA;-Mg and-K allowed the leaf area per plant during the vigourous growth obviously reduced;-P had poorer disease resistance, the disease indexes of all three disease were the highest,-K,-Zn, and-S all had negative influences on disease resistance;the yield of-K was low er,-B,-K had bigger influence on the ratio of high quality leaf, and were 9.2%~9.7% lower than that of FA;-B and-Mg had lower content of total sugar and nicotine while-B had higher content of nitrogen, the total sugar content of treatment-P,-S and-K were higher, and the total N content were lower;-P and-B had bigger influences on the aroma and taste of tobacco leaf.