Abstract: Experiments on the control of cucumber mossaic virus (CMV) in tobacco with salicylic acid (SA) and amino acid (AA) were conducted. Tobacco was treated by application of SA, SA+AA, and SA+AA+microelement a day after inoculation with CMV. These treatments improved growth of tobacco, increased activity of photosynthesis and peroxidase, which is a defensive enzyme. The rate and index of disease were reduced significantly. The best one was SA+AA that effeciny of its control over CMV was 50% The mode of SA and AA action on tobacco is induction of disease resistance.