Abstract: In order to find out the influences of cigarette material parameters on the ammonia delivery in mainstream cigarette smoke, the effects of seven cigarette material parameters, including cigarette paper permeability (X₁), tipping paper permeability(X₂), plug wrapper permeability(X₃), specification of tow in combined filter at tobacco end (X₄), specification of tow in combined filter at mouth end (X₅), filter additive A(X₆), and filter additive B(X₇), on the ammonia delivery in mainstream cigarette smoke were studied by mathematical model and model analysis method, and single factor effect, double factor effect and marginal effect were analyzed. The results showed that: 1) The seven parameters in the order of their effects on ammonia delivery in mainstream cigarette smoke were X₅> X₂=X₄> X₁> X₃> X₇> X₆;2)X₁ and X₄, X₁ and X₅, X₁ and X₇, X₂ and X₄, X₂ and X₅, X₂ and X₇, X₃ and X₄, X₅ and X₆, X₅ and X₇ presented relatively obvious interaction between two factors. 3)X₅ was the most significant factor, the ammonia delivery in mainstream cigarette smoke decreased obviously with the increase of X₅.