Abstract: Titanate nanotube, which could simultaneously remove multiple harmful compounds in mainstream cigarette smoke, was successfully synthesized by a simple hydrothermal process. The synthesized titanate nanotubes were characterized by XRD, SEM, TEM and FT-IR techniques. The results showed that:1) When titanate nanotubes were added into cigarette filter, the deliveries of ammonia, hydrogen cyanide, phenol and crotonaldehyde in mainstream cigarette smoke reduced by 67.53%, 23.52%, 60.81% and 27.56%, respectively; and the selective reduction rates of ammonia and phenol were more than 35%. 2) The adsorption mechanism of titanate nanotube performing on harmful components presented a combined action of physical and chemical adsorption.