Abstract: A pot culture experiment was conducted at seedling stage to study the effects of 6 kinds of amendments (vermiculite, plant ash, peanut shell-biochar, straw-biochar, sepiolite, sodium humate) applied to yellow soil and red soil on decreasing cadmium content in tobacco leaves. The results showed that comparing with the control, amendments (except for plant ash and sodium humate) reduced the cadmium content in tobacco leaves at different extents; the sepiolite application to yellow soil and red soil showed the best effects, the cadmium content in leaves decreased by 32%-42% and 86%, respectively. Biochar was effective only in red soil, cadmium content in leaves decreased by 31%-52%. The available cadmium content in soil treated with different amendments extremely significantly positively correlated (r=0.95, P<0.01)to cadmium content in tobacco leaves, and the function of cadmium content reduction in tobacco leaves was attributed to the reduction of bioavailability of cadmium in soil caused by amendments. Available cadmium content in soil extremely significantly negatively correlated (r=-0.93, P<0.01)to pH in yellow soil, whereas their relationship was not significant in red soil, which explained the different functional mechanisms of amendments in the two kinds of soil.