Abstract: An ultra performance convergence chromatography(UPC²) was developed for analyzing eight important carbonyl compounds in cigarette smoke,wherein the filter pads for trapping the said analytes were treated with derivative reagent.After extracting with acetonitrile,the said analytes were quantitatively analyzed by UPC² equipped with UV detector.Twenty-two cigarette samples were parallel analyzed by this method and the standard method,the obtained data were compared by SPSS software via paired t test.The results showed that:1) All of the eight carbonyl compounds displayed good linearity(R²>0.999) in the range of 0.02-10.00 mg/L.The standard addition recoveries ranged from 75% to 96% with the relative standard deviation less than 10.0%.The limits of detection ranged from 0.07 to 0.15 μg/cigarette.2) The detection time of this method was significantly shorter than that of the standard method.3) There was no significant difference between the data obtained by the two methods with the correlation coefficient of 0.938 and the significance probability of 0.082(> 0.05).4) By taking carbon dioxide as mobile phase,this method consumed less organic solvent and was more environment-friendly,the cost of analysis reduced accordingly.