摘要: A gas chromatography-mass spectrometry (GC-MS) method was developed and validated for simultaneous determination of a number of benzenoids (benzene, toluene, o-xylene, p-xylene, m-xylene, styrene) and other semi-volatile compounds (pyridine and quinoline) in mainstream cigarette smoke. In this method, the particulate matter from mainstream cigarette smoke was trapped by a Cambridge filter pad while the vapor phase of the smoke was trapped by a cold solvent. The target compounds from the two parts were analyzed by GC-MS separately. Two absorption bottles were connected in series and methanol was used as solvent for absorbing the vapor phase. The vapor phase trapping efficiencies of the analytes under different temperatures and trapping devices were investigated. The results showed that the analytes could be effectively trapped at 0 ℃ (by mixing water and ice). The cold trap was easy to set up without the need for special facilities and reagents. Using the method, eight semi-volatile compounds could be simultaneously quantified with good repeatability (relative standard deviation under 8.0%).