摘要: An analytical method for simultaneous determination of four heavy metals, namely chromium (Cr), nickel(Ni), arsenic(As) and lead(Pb) in hot-melt adhesives for cigarette was developed by using inductively coupled plasma mass spectrometry (ICP-MS) with microwave digestion. The method was applied to quantify the four heavy metals in eight hot-melt adhesives. The linear correlation coefficients were between 0.999 and 1.000. The relative standard deviations of measurement were between 2.04% and 4.51% . The recoveries for spiking hot-melt adhesive samples were between 95.2% and 118.1% . The detection and quantitation limits of the method were in the range of 0.012-0.093 μg/L and 0.039-0.309 μg/L, respectively. The uncertainty measurement for the method was evaluated. The calibration curve fitting was the most important factor affecting the combined uncertainty, followed by the standard solution preparation and the repeatability, and with the sample preparation process had the least impact. The levels of the four heavy metals in the hot-melt adhesives were in the order of Cr> Ni> Pb> As. Notable differences in Ni and Pb levels were found with variation coefficients of 86.6% and 81.8%, respectively. The developed method is accurate, simple, rapid, reliable, and suitable for the simultaneous determination of the four heavy metals in hot-melt adhesives for cigarette.