Effects of Permeability of Tipping Paper and Pressure Drop of Filter Rod on Cytotoxicity of Cigarette Smoke

The cytotoxicity of smoke condensate(SC) of cigarettes with tipping paper of different permeability and filter rods of different pressure drop was tested by neutral red uptake assay,and the correlation between cytotoxicity of cigarette smoke and deliveries of CO,NNK,NH₃,HCN,BaP,crotonaldehyde and phenol,was analyzed.The results indicated that:1) The cytotoxicity of cigarette smoke condensate decreased with the increase of tipping paper permeability,and there were certain correlations between cytotoxicity index and the deliveries of CO,NNK,NH₃,HCN,BaP,crotonaldehyde and phenol.2) The cytotoxicity of cigarette smoke condensate decreased with the increase of pressure drop of filter rod,and cytotoxicity index correlated with the deliveries of NH₃,HCN,BaP and phenol.