Synthesis of Monovitamin E Succinate and its Application in Cigarettes

In order to increase the delivery of vitamin E (V_E) in mainstream cigarette smoke and improve smoking taste, monovitamin E succinate was synthesized from V_E and succinic anhydride, the synthetic was analyzed by HPLC, and identified by ¹H NMR, ¹³C NMR and EI-MS. The smoke analysis and sensory evaluation of the cigarettes spiked with the synthetic were carried out. The results showed that: 1) The synthetic was the target product, monovitamin E succinate, with the purity of 98%. 2) The delivery of V_E increased in mainstream smoke of the cigarette spiked with monovitamin E succinate. 3) The smoke irritation of the cigarette containing monovitamin E succinate decreased, and smoking taste improved. monovitamin E succinate has the functions of increasing V_E delivery in mainstream cigarette smoke, reducing smoke irritation, and improving cigarette smoking taste.